Project Leaders Research

 
Buan Thumbnail
Nicole Buan
Kidambi Thumbnail
Srivatsan Kidambi

Armen Petrosyan
Ruiguo Yang
Ruiguo Yang
Limei Zhang
Limei Zhang

The initial cohort of project leaders – five early stage investigators from the Departments of Biochemistry, Chemistry, and Chemical and Biomolecular Engineering – are pursuing projects interrelated by their fundamental focus on different aspects of biomolecular communication within and between cells and tissues. These projects are directed toward identifying molecular metabolic signals of microbial syntrophy in the human gut, developing techniques for high-resolution protein glycoform analysis, unraveling ligand-Stabilin-2 interactions in liver disease progression, designing molecular probes for intracellular phosphorylation kinetics, and developing tissue engineering platforms specifically for liver. The breadth of science encompassed by these projects signifies the interdisciplinary nature of the Center’s research goals.

Buan Outcomes

Metabolic Syntrophy Between Human Gut Bacteria and Archea

Led by Dr. Nicole Buan, this project's goal is to identify molecular metabolic signals of microbial syntrophy in the human gut, with the long-term goal of developing a predictive model relating host diet to healthy gut microbiota resiliency.

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Kidambi Outcomes

In Vitro  Models to Study the Progression of Liver Fibrosis

Led by Dr. Srivatsan Kidambi, this project is expected to have a progressive impact on the study of liver fibrosis and related fields because the availability of a liver model that retains liver microenvironment (LME) will facilitate understanding of the molecular mechanisms that underlie LME activities in mechanisms critical for the maintenance of liver biology.

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