Buan Thumbnail
Nicole Buan
Dodds Thumbnail
Eric Dodds
Harris Thumbnail
Edward Harris
Kidambi Thumbnail
Srivatsan Kidambi
Ruiguo Yang
Armen Petrosyan
Limei Zhang

Modeling and metabolic prediction of healthy and disease-promoting microbiomes

Led by Dr. Nicole Buan, this project is developing approaches to interpret and predict microbial phenotypes based on genomic information and environmental conditions in the host. By applying theoretical concepts onto empirical data, these approaches will be directly applicable to understanding host:microbe interactions that exacerbate or prevent diseases such as irritable bowel syndrome, Crohn’s Disease, and bacterial pathogenic infections.

Dodds Outcomes

Disease-related Protein Glycoforms

Led by Dr. Eric Dodds, this project will develop a thorough chemical understanding of how the most common MS/MS method – collision-induced dissociation (CID) – can alone provide complete connectivity information on N-linked glycopeptides. These insights will be directly applicable to the elucidation of site-specific glycosylation patterns that arise as a result of disease.

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Harris Outcomes

Hepatic Stabilin-2 Mechanisms of Clearance

Led by Dr. Edward Harris, this project will examine the role of liver sinusoidal endothelial cells (LSECs). This study will be the first time that the clearance activity of LSECs has been examined under variant flow to assess activity of Stabilin-2 as the major receptor.

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The role of N-glycan carrying Sialyl-Lewis (x) in progression of prostate cancer

Led by Dr. Armen Petrosyan.

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Stress-Induced Pathway of Cell-Cell Adhesion Disruption in Pemphigus Pathogenesis

Led by Dr. Ruiguo Yang, this project aims to determine the role mechanical stress plays in regulating the pathogenesis of pemphigus, an autoimmune skin disease. With advanced single cell pair interrogation and stimulation techniques, the study will delineate the regulatory mechanisms in adhesive junctions during the cell-cell dissociation processes.  

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A Multifunctional NO-Sensor Controlled by an Iron-Sulfur Cluster Switch

Limei Zhang is an Assistant Professor of Biochemistry at UNL.   Her research addresses critical knowledge gaps in the mechanisms of survival and pathogenesis of Mycobacterium tuberculosis, the causative agent of tuberculosis which poses great threat to public health. Upon completion of the research, we expect to have a better understanding of how this pathogenic organism responds to nitric oxide stress, which is critical for its survival in the host. The outcomes are expected to offer new research directions for designing effective anti-tuberculosis therapeutics. 

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