The central vision of the Nebraska Center for Integrated Biomolecular Communication (CIBC) is to transform our understanding of the mechanisms of information transfer between biomolecules by fostering collaborations between researchers developing innovative methods with those investigating biomedically important questions. The transfer of information between biomolecules is one of the defining aspects of life at the molecular level and is essential for all homeostatic and disease processes. Finely tuned molecular communication networks are disrupted in disease, yet there are many gaps in our fundamental knowledge about how these pathways operate, resulting in an inadequate understanding of the molecular etiology of complex diseases. CIBC is addressing these gaps by developing new analytical tools and integrated research approaches to probe communication pathways within and between cells with high chemical, spatial, and temporal resolution