In Vitro Models to Study the Progression of Liver Fibrosis

FOCμS LAB
Digital Commons

Research Overview

Led by Dr. Srivatsan Kidambi, this project is expected to have a progressive impact on the study of liver fibrosis and related fields because the availability of a liver model that retains liver microenvironment (LME) will facilitate understanding of the molecular mechanisms that underlie LME activities in mechanisms critical for the maintenance of liver biology.

Selected Publications

1. Amita Daverey, Allison Drain, Srivatsan Kidambi*, “Physical Intimacy of Breast Cancer Cells with Mesenchymal Stem Cells Elicits Trastuzumab Resistance through Src Activation” Nature Scientific Reports, doi: 10.1038/srep13744 (Impact Factor = 5.6)
2. Stephen Hayward, David Francis, Parviz Kholmatov, Srivatsan Kidambi*, “Targeted Delivery of MicroRNA-125a-5p by Engineered Lipid Nanoparticles for the Treatment of HER2 positive Metastatic Breast Cancer” Journal of Biomedical Nanotechnology, 2016 doi: 10.1166/jbn.2016.2194 (Impact factor: 5.4)
3. Vaishaali Natarajan, Christina Wilson, Stephen Hayward, Srivatsan Kidambi*, “Mitochondrial Dysregulation and Loss of Hepatic Functions due to Chronic Exposure to Titanium dioxide Nanoparticles to Primary Hepatocytes”, PLOS One, 2015 doi: 10.1371/journal.pone.0134541. (Impact Factor = 3.53) 
4. “In vitro Co-cultures of Breast Cancer Cells and Stromal Cells to Emulate Tumor Progression and miRNA Profiles of Clinical Conditions”, Amita Daverey, Karleen Brown, Srivatsan Kidambi*, Langmuir, 2015 doi: 10.1021/acs.langmuir.5b02227 (Impact Factor = 4.4)
5. “Mitochondrial Dysfunction and Loss of Glutamate Uptake in Primary Astrocytes Exposed to Titanium Dioxide Nanoparticles”, Christina Wilson, Vaishaali Natarajan, Stephen Hayward, Oleh Khalimonchuk, Srivatsan Kidambi*,  Nanoscale, 2015 doi: 10.1039/c5nr03646a (Impact Factor = 7.6)
6. Sunil Kumar, Dhirendra Bahadur, Amita Daverey, Vahid Khalilzad-Sharghi, Niroj Sahu, Niroj; Srivatsan Kidambi, Shadi Othman, “Dye-doped silica encapsulated magnetic nano-assemblies for dual optical/MRI imaging and hyperthermia", RSC Advances, 2015 doi: 10.1039/C5RA07632C (Impact Factor = 3.7)
7. Shyam Sundhar Bale; Nima Saeidi; Srivatsan Kidambi; Martin Yarmush; Monica Casali, “FMR1 Deficiency Alters Self-Renewal, Proliferation, and Pluripotency of Mouse Embryonic Cells”, NanoLife, 2015. doi: 10.1142/S1793984415500038 .
8. Amita Daverey, Allison Drain, Karleen Drain, Srivatsan Kidambi*, “Engineering of highly controlled in vitro co-culture model to study the mesenchymal stem cells mediated signaling in breast cancer cells” Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; Cancer Res 2014; 74 (19 Suppl). doi:10.1158/1538-7445.AM2014-3303
9. Amita Daverey, Austin Mytty, Srivatsan Kidambi*, Topography Mediated Regulation of HER-2 Expression in Breast Cancer Cells”, NanoLife, 2(3), 2012 doi: 10.1142/S1793984412410097.
10. Srivatsan Kidambi*, Joel Yarmush, Yevgeny Berdichevsky, Sangeetha Kamath, Wayne Fong, Joseph SchianodiCola, “Propofol induces MAPK/ERK cascade dependant expression of c-Fos and Egr-1 in rat hippocampal slices” BMC Research Notes, 17(3), 201-206, 2010.