The initial cohort of project leaders – five early stage investigators from the Departments of Biochemistry, Chemistry, and Chemical and Biomolecular Engineering – are pursuing projects interrelated by their fundamental focus on different aspects of biomolecular communication within and between cells and tissues. These projects are directed toward identifying molecular metabolic signals of microbial syntrophy in the human gut, developing techniques for high-resolution protein glycoform analysis, unraveling ligand-Stabilin-2 interactions in liver disease progression, designing molecular probes for intracellular phosphorylation kinetics, and developing tissue engineering platforms specifically for liver. The breadth of science encompassed by these projects signifies the interdisciplinary nature of the Center’s research goals.
Metabolic Syntrophy Between Human Gut Bacteria and Archea
Led by Dr. Nicole Buan, this project's goal is to identify molecular metabolic signals of microbial syntrophy in the human gut, with the long-term goal of developing a predictive model relating host diet to healthy gut microbiota resiliency.Learn More
In Vitro Models to Study the Progression of Liver Fibrosis
Led by Dr. Srivatsan Kidambi, this project is expected to have a progressive impact on the study of liver fibrosis and related fields because the availability of a liver model that retains liver microenvironment (LME) will facilitate understanding of the molecular mechanisms that underlie LME activities in mechanisms critical for the maintenance of liver biology.Learn More